Prof. Dr. Silvio O. Rizzoli

Publications of Silvio O. Rizzoli

 

Hypoxia-stimulated membrane trafficking requires T-plastin.

Wottawa M, Naas S, Böttger J, van Belle GJ, Möbius W, Revelo NH, Heidenreich D, von Ahlen M, Zieseniss A, Kröhnert K, Lutz S, Lenz C, Urlaub H, Rizzoli SO, Katschinski DM.
Acta Physiol (Oxf). 2017 Sep;221(1):59-73. doi: 10.1111/apha.12859. Epub 2017 Mar 23.
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ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N.
J Cell Biol. 2017 Apr 3;216(4):1143-1161. doi: 10.1083/jcb.201606086. Epub 2017 Mar 6.
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Correction: ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N.
J Cell Biol. 2017 Apr 3;216(4):1205. doi: 10.1083/jcb.20160608603092017c. Epub 2017 Mar 13. No abstract available.
PMID: 28289090

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Review of combined isotopic and optical nanoscopy.

Richter KN, Rizzoli SO, Jähne S, Vogts A, Lovric J.
Neurophotonics. 2017 Apr;4(2):020901. doi: 10.1117/1.NPh.4.2.020901. Epub 2017 Apr 22. Review.
PMID: 28466025

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The Membrane Marker mCLING Reveals the Molecular Composition of Trafficking Organelles.

Revelo NH, Rizzoli SO.
Curr Protoc Neurosci. 2016 Jan 4;74:2.25.1-2.25.21. doi: 10.1002/0471142301.ns0225s74.
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Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.

Hassouna I, Ott C, Wüstefeld L, Offen N, Neher RA, Mitkovski M, Winkler D, Sperling S, Fries L, Goebbels S, Vreja IC, Hagemeyer N, Dittrich M, Rossetti MF, Kröhnert K, Hannke K, Boretius S, Zeug A, Höschen C, Dandekar T, Dere E, Neher E, Rizzoli SO, Nave KA, Sirén AL, Ehrenreich H.
Mol Psychiatry. 2016 Jan 26. doi: 10.1038/mp.2015.212. [Epub ahead of print]
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Editorial: Molecular Nanomachines of the Presynaptic Terminal.

Rizzoli SO, Tabares L.
Front Synaptic Neurosci. 2016 Aug 25;8:27. doi: 10.3389/fnsyn.2016.00027. eCollection 2016. No abstract available.PMID: 27610081
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Tools and limitations to study the molecular composition of synapses by fluorescence microscopy.

Maidorn M, Rizzoli SO, Opazo F.
Biochem J. 2016 Oct 15;473(20):3385-3399. Review.
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Optical dissection of experience-dependent pre- and postsynaptic plasticity in the Drosophila brain.

Pech U, Revelo NH, Seitz KJ, Rizzoli SO, Fiala A.
Cell Rep. 2015 Mar 31;10(12):2083-95. doi: 10.1016/j.celrep.2015.02.065. Epub 2015 Mar 26.[Epub ahead of print]
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Super-Resolution Microscopy of Cerebrospinal Fluid Biomarkers as a Tool for Alzheimer’s Disease Diagnostics.

Zhang WI, Antonios G, Rabano A, Bayer TA, Schneider A,Rizzoli SO.
J Alzheimers Dis. 2015 Apr 16. [Epub ahead of print]
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Secondary-ion mass spectrometry of genetically encoded targets.

Vreja IC, Kabatas S, Saka SK, Kröhnert K, Höschen C, Opazo F, Diederichsen U, Rizzoli SO.
Angew Chem Int Ed Engl. 2015 May 4;54(19):5784-8. doi: 10.1002/anie.201411692. Epub 2015 Mar 17.
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The structure and function of presynaptic endosomes.

Jähne S, Helm M, Rizzoli SO.
Exp Cell Res. 2015 Jul 15;335(2):172-9. doi: 10.1016/j.yexcr.2015.04.017. Epub 2015 May 1. Review.
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A contamination-insensitive probe for imaging specific biomolecules by secondary ion mass spectrometry.

Kabatas S, Vreja IC, Saka SK, Höschen C, Kröhnert K, Opazo F, Rizzoli SO, Diederichsen U.
Chem Commun (Camb). 2015 Aug 6;51(67):13221-4. doi: 10.1039/c5cc03895b.
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Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies.

Vreja IC, Nikić I, Göttfert F, Bates M, Kröhnert K, Outeiro TF, Hell SW, Lemke EA, Rizzoli SO.
ACS Nano. 2015 Oct 28. [Epub ahead of print].
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Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T.
EMBO J. 2015 Nov 3;34(21):2686-702. doi: 10.15252/embj.201591885. Epub 2015 Oct 7.
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FM dye photo-oxidation as a tool for monitoring membrane recycling in inner hair cells.

Kamin D, Revelo NH, Rizzoli SO, Yan A, Levy M.
PLoS One. 2014 Feb 5;9(2):e88353. doi: 10.1371/journal.pone.0088353. eCollection 2014.
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Synaptic vesicle recycling: steps and principles.

Rizzoli SO.
EMBO J. 2014 Apr 16;33(8):788-822. doi: 10.1002/embj.201386357. Epub 2014 Mar 3.
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Correlated optical and isotopic nanoscopy.

Saka SK, Vogts A, Kröhnert K, Hillion F, Rizzoli SO, Wessels JT.
Nat Commun. 2014 Apr 10;5:3664. doi: 10.1038/ncomms4664.
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Fluorescent in situ hybridization of synaptic proteins imaged with super-resolution STED microscopy.

Zhang WI, Röhse H, Rizzoli SO, Opazo F.
Microsc Res Tech. 2014 Apr 10. doi: 10.1002/jemt.22367.
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A new probe for super-resolution imaging of membranes elucidates trafficking pathways.

Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO.
J Cell Biol. 2014 May 26;205(4):591-606. doi: 10.1083/jcb.201402066.
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Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.

Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, Rizzoli SO.
Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
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Multi-protein assemblies underlie the mesoscale organization of the plasma membrane.

Saka SK, Honigmann A, Eggeling C, Hell SW, Lang T, Rizzoli SO.
Nat Commun. 2014 Jul 25;5:4509. doi: 10.1038/ncomms5509.
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Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF.
PLoS Genet. 2014 Nov 13;10(11):e1004741. doi: 10.1371/journal.pgen.1004741. eCollection 2014 Nov.
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Spontaneous vesicle recycling in the synaptic bouton.

Truckenbrodt S, Rizzoli SO.
Front Cell Neurosci. 2014 Dec 8;8:409. doi: 10.3389/fncel.2014.00409. eCollection 2014. Review.
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FM dye photoconversion for visualizing synaptic vesicles by electron microscopy.

Hoopmann P, Rizzoli SO, Betz WJ.
Cold Spring Harb Protoc. 2012 Jan 1;2012(1):84-6. doi: 10.1101/pdb.prot067611.
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Imaging synaptic vesicle recycling by staining and destaining vesicles with FM dyes.

Hoopmann P, Rizzoli SO, Betz WJ.
Cold Spring Harb Protoc. 2012 Jan 1;2012(1):77-83. doi: 10.1101/pdb.prot067603. Review.
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An RNA alternative to human transferrin: a new tool for targeting human cells.

Wilner SE, Wengerter B, Maier K, de Lourdes Borba Magalhães M, Del Amo DS, Pai S, Opazo F, Rizzoli SO, Yan A, Levy M.
Mol Ther Nucleic Acids. 2012 May 15;1:e21. doi: 10.1038/mtna.2012.14.
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Super-resolution imaging prompts re-thinking of cell biology mechanisms: selected cases using stimulated emission depletion microscopy.

Saka S, Rizzoli SO.
Bioessays. 2012 May;34(5):386-95. doi: 10.1002/bies.201100080. Epub 2012 Mar 13.
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Use-dependent inhibition of synaptic transmission by the secretion of intravesicularly accumulated antipsychotic drugs.

Tischbirek CH, Wenzel EM, Zheng F, Huth T, Amato D, Trapp S, Denker A, Welzel O, Lueke K, Svetlitchny A, Rauh M, Deusser J, Schwab A, Rizzoli SO, Henkel AW, Müller CP, Alzheimer C, Kornhuber J, Groemer TW.
Neuron. 2012 Jun 7;74(5):830-44. doi: 10.1016/j.neuron.2012.04.019.
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The Aspergillus nidlans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism.

Bayram Ö, Bayram ÖS, Ahmed YL, Maruyama J, Valerius O, Rizzoli SO, Ficner R, Irniger S, Braus GH.
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18944-9. doi: 10.1073/pnas.1203306109. Epub 2012 Oct 25.
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Imaging synaptic vesicle recycling using FM dyes.

Hoopmann P, Rizzoli SO, Betz WJ
Book chapter in: Imaging in Neuroscience: A Laboratory Manual. Editors: Fritjof Helmchen,


Systematic heterogeneity of fractional vesicle pool sizes and release rates of hippocampal synapses.

Welzel O, Henkel AW, Stroebel AM, Jung J, Tischbirek CH, Ebert K, Kornhuber J, Rizzoli SO, Groemer TW.
Biophys J. 2011 Feb 2;100(3):593-601. doi: 10.1016/j.bpj.2010.12.3706.
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A small pool of vesicles maintains synaptic activity in vivo.

Denker A, Bethani I, Kröhnert K, Körber C, Horstmann H, Wilhelm BG, Barysch SV, Kuner T, Neher E, Rizzoli SO.
Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17177-82. doi: 10.1073/pnas.1112688108. Epub 2011 Sep 8.
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The reserve pool of synaptic vesicles acts as a buffer for proteins involved in synaptic vesicle recycling.

Denker A, Kröhnert K, Bückers J, Neher E, Rizzoli SO.
Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17183-8. doi: 10.1073/pnas.1112690108. Epub 2011 Sep 8.
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Studying synaptic vesicle pools using photoconversion of styryl dyes.

Opazo F, Rizzoli SO.
J Vis Exp. 2010 Feb 15;(36). doi:pii: 1790. 10.3791/1790.
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Structure and dynamics of a two-helix SNARE complex in live cells.

Halemani ND, Bethani I, Rizzoli SO, Lang T.
Traffic. 2010 Mar;11(3):394-404. doi: 10.1111/j.1600-0854.2009.01020.x. Epub 2009 Nov 19.
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Membrane protein clusters at nanoscale resolution: more than pretty pictures.

Lang T, Rizzoli SO.
Physiology (Bethesda). 2010 Apr;25(2):116-24. doi: 10.1152/physiol.00044.2009. Review.
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t-SNARE protein conformations patterned by the lipid microenvironment.

Rickman C, Medine CN, Dun AR, Moulton DJ, Mandula O, Halemani ND, Rizzoli SO, Chamberlain LH, Duncan RR.
J Biol Chem. 2010 Apr 30;285(18):13535-41. doi: 10.1074/jbc.M109.091058. Epub 2010 Jan 21.
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Synaptic membrane proteins form stable microdomains in early endosomes.

Geumann U, Schäfer C, Riedel D, Jahn R, Rizzoli SO.
Microsc Res Tech. 2010 Jun;73(6):606-17. doi: 10.1002/jemt.20800.
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A fluorescence-based in vitro assay for investigating early endosome dynamics.

Barysch SV, Jahn R, Rizzoli SO.
Nat Protoc. 2010 Jun;5(6):1127-37. doi: 10.1038/nprot.2010.84. Epub 2010 May 27.
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Limited intermixing of synaptic vesicle components upon vesicle recycling.

Opazo F, Punge A, Bückers J, Hoopmann P, Kastrup L, Hell SW, Rizzoli SO.
Traffic. 2010 Jun;11(6):800-12. doi: 10.1111/j.1600-0854.2010.01058.x. Epub 2010 Mar 9.
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Comparing video-rate STED nanoscopy and confocal microscopy of living neurons.

Lauterbach MA, Keller J, Schönle A, Kamin D, Westphal V, Rizzoli SO, Hell SW.
J Biophotonics. 2010 Jul;3(7):417-24. doi: 10.1002/jbio.201000038.
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High- and low-mobility stages in the synaptic vesicle cycle.

Kamin D, Lauterbach MA, Westphal V, Keller J, Schönle A, Hell SW, Rizzoli SO.
Biophys J. 2010 Jul 21;99(2):675-84. doi: 10.1016/j.bpj.2010.04.054.
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The fate of synaptic vesicle components upon fusion.

Opazo Rizzoli SO.
Commun Integr Biol. 2010 Sep;3(5):427-9. doi: 10.4161/cib.3.5.12132.
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Synaptic vesicle pools: an update.

Denker A, Rizzoli SO.
Front Synaptic Neurosci. 2010 Oct 5;2:135. doi: 10.3389/fnsyn.2010.00135.
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Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis.

Pavlos NJ, Grønborg M, Riedel D, Chua JJ, Boyken J, Kloepper TH, Urlaub H, Rizzoli SO, Jahn R.
J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
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Endosomal sorting of readily releasable synaptic vesicles.

Hoopmann P, Punge A, Barysch SV, Westphal V, Bückers J, Opazo F, Bethani I, Lauterbach MA, Hell SW, Rizzoli SO.
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19055-60. doi: 10.1073/pnas.1007037107. Epub 2010 Oct 18.
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The same synaptic vesicles drive active and spontaneous release.

Wilhelm BG, Groemer TW, Rizzoli SO.
Nat Neurosci. 2010 Dec;13(12):1454-6. doi: 10.1038/nn.2690.
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The mobility of synaptic vesicles.

Kamin D,Rizzoli SO.
Neuroforum 15:84-92.


Video-rate far-field optical nanoscopy dissects synaptic vesicle movement.

Westphal V*, Rizzoli SO*, Lauterbach MA, Kamin D, Jahn R, Hell SW.
*equal first authors
Science. 2008 Apr 11;320(5873):246-9. doi: 10.1126/science.1154228. Epub 2008 Feb 21.
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Dual-color STED microscopy at 30-nm focal-plane resolution.

Meyer L, Wildanger D, Medda R, Punge A, Rizzoli SO, Donnert G, Hell SW.
Small. 2008 Aug;4(8):1095-100. doi: 10.1002/smll.200800055. No abstract available.
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3D reconstruction of high-resolution STED microscope images.

Punge A, Rizzoli SO, Jahn R, Wildanger JD, Meyer L, Schönle A, Kastrup L, Hell SW.
Microsc Res Tech. 2008 Sep;71(9):644-50. doi: 10.1002/jemt.20602.
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SNARE function is not involved in early endosome docking.

Geumann U, Barysch SV, Hoopmann P, Jahn R, Rizzoli SO.
Mol Biol Cell. 2008 Dec;19(12):5327-37. doi: 10.1091/mbc.E08-05-0457. Epub 2008 Oct 8.
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Two-color far-field fluorescence nanoscopy.

Donnert G, Keller J, Wurm CA, Rizzoli SO, Westphal V, Schönle A, Jahn R, Jakobs S, Eggeling C, Hell SW.
Biophys J. 2007 Apr 15;92(8):L67-9. Epub 2007 Feb 16.
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The specificity of SNARE pairing in biological membranes is mediated by both proof-reading and spatial segregation.

Bethani I, Lang T, Geumann U, Sieber JJ, Jahn R, Rizzoli SO.
EMBO J. 2007 Sep 5;26(17):3981-92. Epub 2007 Aug 23.
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Endocytosis in neurons: editorial introduction and overview.

Jahn R, Rizzoli SO.
Traffic. 2007 Sep;8(9):1121-2. Epub 2007 Jul 20. No abstract available.
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Kiss-and-run, collapse and ‚readily retrievable‘ vesicles.

Rizzoli SO, Jahn R.
Traffic. 2007 Sep;8(9):1137-44. Epub 2007 Jul 20. Review.
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Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity.

Brandhorst D*, Zwilling D*, Rizzoli SO*, Lippert U, Lang T, Jahn R.
*equal first authors
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2701-6. Epub 2006 Feb 9.
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STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis.

Willig KI*, Rizzoli SO*, Westphal V, Jahn R, Hell SW.
*equal first authors
Nature. 2006 Apr 13;440(7086):935-9.
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Macromolecular-scale resolution in biological fluorescence microscopy.

Donnert G, Keller J, Medda R, Andrei MA, Rizzoli SO, Lührmann R, Jahn R, Eggeling C, Hell SW.
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11440-5. Epub 2006 Jul 24.
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Mobility of synaptic vesicles in different pools in resting and stimulated frog motor nerve terminals.

Gaffield MA, Rizzoli SO, Betz WJ.
Neuron. 2006 Aug 3;51(3):317-25.
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Evidence for early endosome-like fusion of recently endocytosed synaptic vesicles.

Rizzoli SO, Bethani I, Zwilling D, Wenzel D, Siddiqui TJ, Brandhorst D, Jahn R.
Traffic. 2006 Sep;7(9):1163-76.
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5>Synaptic vesicle pools.

Rizzoli SO, Betz WJ.
Nat Rev Neurosci. 2005 Jan;6(1):57-69. Review.
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Modulation of nicotinic acetylcholine and N-methyl-d-aspartate receptors by some Hymenopteran venoms.

Zalat S, Elbana S, Rizzoli SO, Schmidt JO, Mellor IR.
Toxicon. 2005 Sep 1;46(3):282-90.
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The structural organization of the readily releasable pool of synaptic vesicles.

Rizzoli SO, Betz WJ.
Science. 2004 Mar 26;303(5666):2037-9.
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Effects of wortmannin and latrunculin A on slow endocytosis at the frog neuromuscular junction.

Richards DA, Rizzoli SO, Betz WJ.
J Physiol. 2004 May 15;557(Pt 1):77-91. Epub 2004 Mar 5.
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Imaging synaptic vesicle dynamics with styryl dyes

Rizzoli SO, Becherer U, Angleson J, Betz WJ.
Book chapter in: Imaging In Neuroscience and Development. Editors: Rafael Yuste and Editors: Rafael Yuste and Athur Konnerth. Cold Spring Harbor Laboratory Press.

Neurobiology: All change at the synapse.

Rizzoli SO, Betz WJ.
Nature. 2003 Jun 5;423(6940):591-2. No abstract available.
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Monitoring synaptic vesicle recycling in frog motor nerve terminals with FM dyes.

Rizzoli SO, Richards DA, Betz WJ.
J Neurocytol. 2003 Jun-Sep;32(5-8):539-49. Review.
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Synaptic vesicle pools at the frog neuromuscular junction.

Richards DA, Guatimosim C, Rizzoli SO, Betz WJ.
Neuron. 2003 Jul 31;39(3):529-41.
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Calcium rise in cultured neurons from medial septum elicits calcium waves in surrounding glial cells.

Rizzoli S, Sharma G, Vijayaraghavan S.
Brain Res. 2002 Dec 13;957(2):287-97.
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Effects of 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one on synaptic vesicle cycling at the frog neuromuscular junction.

Rizzoli SO, Betz WJ.
J Neurosci. 2002 Dec 15;22(24):10680-9.
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IgG isolated from LP-BM5 infected mouse brain activates ionotropic glutamate receptors.

Rizzoli S, Rogawski MA, Usherwood PN.
Neurobiol Dis. 2001 Dec;8(6):1069-81.
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Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.

Strømgaard K, Bjørnsdottir I, Andersen K, Brierley MJ, Rizzoli S, Eldursi N, Mellor IR, Usherwood PN, Hansen SH, Krogsgaard-Larsen P, Jaroszewski JW.
Chirality. 2000 Feb;12(2):93-102.
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